This comprehensive guide explores the requirements for transporting animals across state lines in the United States, focusing on essential vaccinations and necessary documentation. It outlines the importance of rabies vaccination and other core vaccines for dogs and cats, detailing the Certificate of Veterinary Inspection (CVI) and rabies vaccination certificates required for interstate travel. The article emphasizes the significance of understanding state-specific regulations and the special considerations for vulnerable animals, such as young or sick livestock. Additionally, it provides resources for further information, ensuring pet owners are well-prepared for safe and legal animal transport.